Comparative Study on Cardiovascular Autonomic Function Tests in Type 2 Diabetes Mellitus Patients with and without Diabetic Retinopathy

Authors

  • Juhi Agrawal, Subodh Pandey, Sachin Chittawar, Vivek Som

DOI:

https://doi.org/10.37506/ijop.v7i3.162

Keywords:

Diabetes mellitus, Autonomic neuropathy, Autonomic function tests.

Abstract

Introduction

Autonomic dysfunction is common in diabetics and presence of cardiac autonomic neuropathy is responsible for sudden death in diabetics. Detecting subclinical Cardiac Autonomic Neuropathy (CAN) early is crucially important for treatment and for preventing potentially serious consequences of CAN.

Aims and Objectives

The aim of the study is to clinically assess cardiovascular autonomic function tests in type 2 diabetes mellitus patients and compare those with healthy normal subjects.

Method

The study included 60 type 2 diabetic patients including 30 patients without any retinopathy and 30 others with non-proliferative diabetic retinopathy(NPDR), and 60 control subjects matched for age and gender. Autonomic function tests as given by Ewing were performed on all subjects to assess the parasympathetic and sympathetic nervous activity. These tests include heart rate response to deep breathing, valsalsa ratio, 30: 15 ratio, and blood pressure response to standing and sustained hand grip. Statistical analysis of the data was done using One way ANOVA (Analysis of Variance) and multiple comparisons were done using post hoc Tukey Multiple Comparison Test. Statistical significance was set at 0.05.

Results

The results of our study show that there is decrease in cardiovascular autonomic functions more in diabetic patients with NPDR as compared to diabetic patients without retinopathy.

Conclusion

We conclude that there is involvement of both cardiovasvascular sympathetic and parasympathetic nervous system in patients with type 2 diabetes mellitus. So, type 2 DM patients should be evaluated for presence of autonomic dysfunction as early as possible to prevent complications and to improve the prognosis of the disease.

Author Biography

  • Juhi Agrawal, Subodh Pandey, Sachin Chittawar, Vivek Som

    Agrawal Juhi1, Pandey Subodh2,*, Chittawar Sachin3, Som Vivek4

    1Demonstrator, Department of Physiology, Gandhi Medical College, Bhopal

    2Prof and Head, Department of Physiology, Gandhi Medical College, Bhopal

    3Associate Prof, Department of Medicine, Gandhi Medical College, Bhopal

    4Associate Prof, Department of Ophthalmology, Gandhi Medical College, Bhopal

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Published

2019-07-25

How to Cite

Comparative Study on Cardiovascular Autonomic Function Tests in Type 2 Diabetes Mellitus Patients with and without Diabetic Retinopathy. (2019). International Journal of Physiology, 7(3), 202-208. https://doi.org/10.37506/ijop.v7i3.162