Baroreflex Sensitivity in Chronic Obstructive Pulmonary Disease and its Correlation with Disease Severity-in South Indian Population
DOI:
https://doi.org/10.37506/ijop.v8i2.1241Keywords:
Autonomic dysfunction, BRS, COPD, Cardiovascular risk, FEV1, GOLD criteria.Abstract
Background: Chronic obstructive pulmonary disease (COPD) is systemic disorder which causes autonomic
dysfunction and predisposes patients to cardiovascular mortality and morbidity. FEV1 is a predictor of
cardiovascular events in COPD patients and Baroreflex sensitivity (BRS) is most reliable tool to measure
autonomic dysfunction. There is paucity of literature, revealing the relationship of BRS with disease severity
in COPD patients.
Objective: In our study we intended to assess BRS among different stages of COPD (GOLD CRITERIA)
and also identify the association of BRS with disease severity.
Method: This study was done in collaboration between Department of Physiology & Department of
Pulmonary medicine, JIPMER. It is a descriptive study done on (n=130) male COPD patients. Anthropometric
parameters (height, weight, BMI, W/H ratio), basal parameters, BRS (using Finapres) & PFT (using Spirolab
III) parameters were assessed in them. Later, based on the GOLD stage criteria (Mild, Moderate, Severe,
Very severe) they were divided into 4 sub-groups. Data was analyzed by SPSS 16.0 version software.
One-way ANOVA (>2 groups) was used to find any Statistical difference between the groups. Correlations
between the variables were done using Pearson correlation test.
Results: Statistically significant (p<0.05)difference in BRS between different stages of COPD was determined
by Kruskal- Wallis test and the post – hoc (Dunn’s) test revealed that BRS levels were significantly reduced
in very severe, severe and moderate COPD patients when compared to mild COPD patients. Significant
positive Correlation (r=.332, p=0.05) was found between BRS and FEV1.
Conclusion: Baroreflex sensitivity is reduced in male patients of COPD and BRS correlated with lung
function and disease severity.
Downloads
Published
Issue
Section
License
Copyright Ownership: Authors retain copyright ownership of their work after publication in IJOP. However, they grant the journal an exclusive Creative Commons license.
Creative Commons License: The authors grant IJOP the right to exclusively apply a Creative Commons license to their work upon publication. This license permits use, distribution, and reproduction of the work in any medium, provided that the original work and its source are properly cited. The specific license applied is Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0), which allows for attribution, non-commercial use, and derivative works.
Editorial Research: Authors grant the journal the right to analyze information obtained from submitted manuscripts for editorial research purposes. This analysis aims to improve the peer-review process, teaching, and training activities.
Warranties: Authors warrant that their work is original, contains no libelous statements, is lawful, and does not infringe upon any copyright, trademark, patent, or proprietary rights of others. Authors agree to indemnify the editors against any costs, expenses, and damages arising from any breach of this warranty.
Views and Opinions: The views and opinions expressed in the article are those of the authors and not necessarily those of the journal.