An Observational and Comparative Study of Diurnal Variation of Spirometry Test Parameters among First and Second Year Normal and Healthy Medical Undergraduate Students
DOI:
https://doi.org/10.37506/ijop.v8i2.1256Keywords:
Spirometry test, Pulmonary Function Test, Diurnal variability, FEV1, PEF.Abstract
Introduction: This study was designed to assess and compare diurnal variability of FEF25, FEF50, FEF75,
FEF25-75, PEF and FEV1 by measuring these parameters during morning and evening hours in normal
healthy subjects.
Materials and Method: 190 students were enrolled and divided intogroupsof 8-10 students. Each group
were directed to appear at different dates in Pulmonary Function Test (PFT) Laboratory at 7:30 AM and again
at 5:00 PM for spirometry testing. Spirometry was performed with Spiro Excel 1.1 as per the ATS guidelines
and by trained technician. Finally, data from 169 subjects was found to be complete and appropriate and
was taken for the analysis.Diurnal variability in FEF25, FEF50, FEF75, FEF25-75, PEF and FEV1 were
determined and compared.
Results: Allparameters were more in male than female. All the parameters were significantly high in evening
tests as compared to morning tests except FVC. Diurnal variability among different spirometry parameters
was significantly different (ANOVA, p<0.05) in morning and evening tests. The diurnal variability was
highest in large airways as reflected by FEF75 and lowest in smaller airways as reflected by FEF25.
The diurnal variability was lowest for FEV1%. It revealed that all parameters exhibit significant diurnal
variability.
Conclusion: FEV1, FEF and PEF had shown diurnal variability which was directly related to the airway
calibre. Greater variability was seen in PEF as compared to FEV1 i.e. proximal airways showed greater
diurnal variation than distal airways.
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