The Nature of the Il17 Cytokine Response In Rabbits PrimeBoosted With Eschrchia Coli-Pseudomonas Aeruginosa  Prototype Bacterin Combinations

Authors

Bacterin, Combination,enhance ,Immune, interference ,inhibition.

The prototype E .coli - P. aeruginosa heat killed bacterin balanced and unbalanced bacterin combinations,as

well as monotypic E. coli and single P. aeruginosa bacterins were developed. They were prime-boosted

rabbits by homologous prime-boost protocols. At the end of the specific immune-priming protocols ,rabbits

were bleed, sera saved in 0.5 ml aliquots at -18C till testing due time.IL17 Eliza assay was done on the test

and control sera. Single strength balanced combined bacterin combination induced increase in the mean

IL17 concentration means as compared to monotypic, double balanced ,un-balanced bcterin combinations

and control. The other combinations were showing inhibition in IL17 concentration means than control .The

immune interference matched To as: one bacterin enhance the other, and one damp the other. Enhancement of

IL17 response single strength combination might be a promise for efficacy of such combination in regulation

and protection against natural or experimental infectious challenges .

Ibrahim Ms Shnawa1 , Ferial Abd2

1 Prof. Department of Biotechnology, College of Biotechnology/ University of Al-Qasim Green/ Qasim, Babylon,

IRAQ, 2 Prof. Department of Biology, College of Science/ University of Babylon/ IRAQ