Evaluation of the Immune Response in Scabies Patient  (Ordinary and Prisoners) Treated with Permethrin 5%

Authors

Kawther Omran Hashim1 , Maan Abdul Aziz Shafiq1 , Hazima Mossa Al-Abassi2 , Majid Mohammed Mahmood1

Scabies,IL-4, IL-9, totalIgE.

Scabies is a common parasitic infection, caused by sarco-sarcoptes, the infection occurs when the Sarcoptes

penetrates the corneal layer of the skin, predominant pathological manifestations, through inflammatory and

allergic reactions to mite products.This study is designed to obtain the Evaluation of the immune response

in scabies patient (Ordinary and Prisoners) treated with Permethrin 5%.The study included (28)Ordinary

Scabies patients, (32) prisonersas well as a (30)healthy person as a control group. Blood samples were

collected from all studied groups Enzyme-linked immunosorbent assay (ELISA) was used to measure

Interleukine-4,IL-9 and total IgE.Results of the study showed that serum,IL-4 showed a significant (P?0.

0001) increasing in prisoners compared to ordinary patients and control groups(248.8±19.3vs.79.2±10.7pg/

ml),(248.8±19.3vs.73.9±5.5pg/ml)respectively,while IL-9 showed a significant (P? 0.001), increasing in

control compared to Ordinary Scabies patients group and prisoners (506.9±48.7vs.337.8±18.2 pg/ml),

(506.9±48.7 vs. 424.1±36.5 pg/ml) respectively in post- treatment, There was positive correlation between

(IL-4 and IgE).Levels of two cytokines (IL-4, and IL-9) were assessed in sera of Ordinary ScabiesPatients

and control group, IL-4 showed a significant (P?0. 0001) increasing in Ordinary Scabies comparedto control

group (92.5±7.0 vs. 73.9 ± 5.5pg/ml), respectively. While IL-9with asignificant decreasinglevel inOrdinary

Scabies patients compared to control group(97.8 ±18.8 vs. 506.9 ±48.7 pg/ml) in pre-treatment, level of

IgE were recorded in pre- treatment in ordinary patients and prisoners (314.8±37.5 vs. 17.8±3.7 IU/ml),

(372.7±37.5 vs. 17.8±3.7 IU/ml) respectively, were a significantly increasing (P=>0.05) as compared to

healthy control. In post- treatment IgE levels show a significantly lowering (P=>0.05), in prisoners than

Ordinary patients(14.5±1.7 vs. 33.3±2.4 IU/ml).

Kawther Omran Hashim1 , Maan Abdul Aziz Shafiq1 , Hazima Mossa Al-Abassi2 , Majid Mohammed Mahmood1

1 Department of Biology, College of science, Mustansiriyah University, Iraq, 2Department of Biology, College of

Education for Pure Sciences-IbnAl Haytham, University of Baghdad, Iraq