Correlation between Serum Interleukin-33 Level and Uterine Fibroids

Abstract

Introduction: Fibroid is considered the most common benign tumor of the female genital system; it has
vague incidence and etiology. IL33 is thought to play a role in pathogenesis and this may open the doors to
further understanding and treatment of this disease.
Aim of the study: To assess if there is any correlation between IL33 serum level and uterine fibroid and if
there is correlation with tumor features such as size, site and number.
Method: We take 40 women with leiomyoma and 40 leiomyoma free women at this case control study. For
both of them history and physical examination was done with diagnosis supported by US, serum is collected
and IL33 level was compared between both groups.
Results: Mean age of patients is 36 years most of them are married, over-weight, para 1-3 and has history of
breast-feeding. Commonest presentation is HMB about 80% the least is dyspareunia, 36.8% had history of
infertility, the majority of fibroids were intramural & multiple. There was higher IL33 levels among cases.
Conclusion: there is significant correlation between IL33 serum levels and presence of uterine leiomyoma
and there was significant correlation with size of fibroid while there was no correlation with the site and
number of fibroid.