Assessment of Serum Interleukin-4 and Filaggrin Protein in Patients with Atopic Dermatitis

Abstract

The current study aimed to determine the relationship between certain immunological parameters inatopic
dermatitis (AD) patients.
There wasno significant differences (P?0.05)in the level offilaggrin protein between patients and control
groups regarding to the age but there wasa significant differences (P? 0.05)in the level of IL-4 between
patients and healthy subjects groups regarding to the age, also the study showed that there was no significant
differences (P?0.05) between study groups regarding the gender for above two parameters.
The data of current study support the defected skin barrier role in the AD pathogenesis, in addition the
results revealedfilaggrin reduced expression in atopic skin lesion and inverse correlation between filaggrin
protein expression and disease severity. Add to that, the elevation of circulation interleukin IL-4 levels in
AD, emphasizes the profile of systemic inflammation of this skin barrier defective dermatosis.