Evaluating of Serum Electrolyte Changes in Chronic Renal Failure Pre and Post Dialysis

Abstract

Background: The kidney playedvital role in the regulation of electrolyte and acid–base balance. With
progressive loss of renal function, derangements in electrolytes and acid–base certainlyoccurred and
contribute to worse patientoutcomes.
Objective: The aim of the present study is to assess the effect of Hemodialysis (HD) on serum electrolytes
levels which compared with healthy controlgroup; also to assess the correlation of serum electrolyte before
and after hemodialysis.
Material and Method: The study done on 40 patients (25 men and 15 women) all patients with chronic
kidney disease, ages of patients 25 – 65 years. All patients enter the dialysis department in Merjan teaching
hospital and matched with 30 well persons as control. Results: study of comparison between patients before
and after hemodialysis, significant difference in the level of serum urea and creatinine between pre and
post dialysis, and significant effect of Hemodialysis on serum electrolytes particularly serum potassium
levels. The pre-hemodialysis K+ was 4.48± 0.83 mmol/L and post-hemodialysis K+ was 3.69±0.65 mmol/L
(P<0.001). The pre-hemodialysis Na+ was136.5±4.14 and post - hemodialysis Na+ was 138.6 ±4.41 (P = 0.
36). The pre- hemodialysis Cl-
was 106.12 ± 4.02 and post-hemodialysis Cl-
was 107.12 ± 4.11 (P= 0.38
NS).
Conclusion: There is decrease in s. urea besides creatinine level between period before and afterhemodialysis.
Serum K+ level decreased after hemodialysis. Although serum sodium and chloride levels not significantly
affected after hemodialysis.