Serum Levels of Irisin and Vaspin in Diabetic Retinopathy Patients and Their Relation to Patient’s Obesity

Abstract

The s study was carried out in Kirkuk city, from 20th January to September to November 2019 included
40 Diabetic patients with retinopathy and 40 healthy persons within the range of age: 45-75 years of
old. The information about patients in this study was retrieved from patient’s itself. The diabetic patients
with retinopathy were diagnosed by analysis RBS and HbA1c and fundoscopical examination by the
ophthalmologist. The criteria of exclusion include non-diabetic and malignant disease. The results of the
patients groups were compared with healthy individuals nearly comparable age and BMI. Four ml of blood
were collected from patients and for determination of irisin, vaspin and HbA1c. The study showed that the
mean serum level of irisin was significantly elevated in DR patients compared to control group (27.57 ±
4.22 and 17.57 ± 5.9 pg/ml) respectively at a P value < 0.01.This study showed that the mean serum level
vaspin was higher in DR patients especially in persons with high BMI and decreased in lower BMI persons
(75.1, 59.3 and 48.3 ng/ml)respectively but still higher than healthy ones (P<0.01), as compared with the
control group (32.17ng/ml). The study showed that, HbA1c was elevated significantly (P<0.01) in diabetic
retinopathy patients (10.17%) compared with healthy control (5.17%),. The study concluded that, vaspin
and irisin levels were highly elevate din diabetic patients with retinopathy