The Effect of Esomeprazole on Cell Line Human Cervical Cancer

Abstract

Esomeprazole is an inhibitor of the proton pump that reduces gastric acidity and is used in indigestion treatment; Esomeprazole is a promising treatment for tumors, such as melanoma and B cell leukemia, through several mechanisms, including rapid cellular acidification and activation of many types of caspase enzymes, which in turn lead to the activation of cellular apoptosis
This work was designed to assess the toxicity of the (Esomeprazole) on (HeLa cell line) in vitro at concentrations starting from one - ten thousand ?g/ milliliter and compared with cytotoxicity of vincristine and methotrexate at concentrations between one - ten thousand ?g/ milliliter In 3 incubation periods
The results showed that the cellular toxicity of one ?g / milliliter was a lot of more than the cellular toxicity of ten and a hundred ?g / milliliter. The results additionally showed that toxicity of esomeprazole was considerably more than vincristine and methotrexate on HLA cells at seventy two hours.