The impact of L-carnitine Supplement on Semen Variables and the Levels of Sexual Hormones (Serum LH, FSH, Testosterone, and Inhibin) in Males with Infertility

Abstract

Background: It had been estimated that tenth of partners had infertility, and in approximately half of these cases, the imperfection can be ascribed to male related causes. Fecundity in men necessitate regular functioning hypothalamus, pituitary gland, and testes axis. aberrant spermatogenesis is habitually incorporated to permuted serum gonadotropins and testosterone. L-carnitine is an supreme antioxidant existing in a lofty concentration in epididymal excretions. It affords liveliness for sperms to earn their dynamism in the epididymis.
Aim: The study proposed to explore the effect of L-carnitine supplement on semen parameters, and sex hormones milieu in patients with primary or secondary infertility.
Patients and Methods: A clinical trial conducted on a 58 patients(mean age± SD: 30.6 ± 6.07) treated with 2gm of L carnitine, which prescribed orally at a daily dose of 2gm a day in divided doses for 3 months. Before, and after the end of the L-carnitine treatment, semen analysis and serum levels of LH, FSH, Testosterone, and inhibin were performed.
Results: The mean values of sperm count, total motility and normal morphology of and oligo-astheno-teratospermic were found notably changed (p<0.05) with 3 months carnitine supplement. The outcome of this trial exhibited that L-carnitine supplement can improve sperm concentration, and count, as well active motility. Additionally it has been noticed that the serum gonadotropin (FSH and LH) levels were noteworthy declined, while serum testosterone and inhibin levels were upraised in infertile males when compared with the levels before, the 3 months course of L-carnitine treatment.